Table 2. Diagnostic test results, management, and outcome for persons with Anncaliia algerae myositis*.
| Variable† | Case-patient A | Case-patient B | Case-patient 1 (3) | Case-patient 2 (5) | Case-patient 3 (8) |
|---|---|---|---|---|---|
| Hemoglobin, g/L (130–180)‡ | 95 | 122 | ND | 100 | 96 |
| Lymphocytes ×109/L (1.5–4.0) | 0.3 | 0.4 | ND | 0.2 | 0.1 |
| CK U/L, peak (<200) | 2,028 | 6,630 | 6,337 | 685 | 441 |
| ALT, U/L (<45) | 154 | 93 | ND | 66 | 50 |
| AST, U/L (<45) | 320 | 210 | ND | 129 | 70 |
| ESR, mm/hr (0–14) | 85 | 26 | ND | 38 | 30 |
| CRP, mg/L (<3) | 152 | 134 | ND | 16 | 41 |
| Serum albumin, lowest, g/L (33–48) | 21 | 19 | ND | 19 | 14 |
| Serum creatinine, µmol/L (60–100)§ | 44 | 202 | ND | 81 | 216 |
| Urinary protein, g/24 h (<0.1)¶ | 0.56 | 1.8 | ND | NT | 1.53 |
| Fecal stain# | No microsporidia | NT | ND | No microsporidia | No microsporidia |
| Neurophysiology/EMG | Myopathy; axonal neuropathy | Myopathy; axonal neuropathy | ND | Myopathy; axonal neuropathy | Myopathy; axonal neuropathy |
| Negative biopsy/fluid sites | CSF | Esophagus, stomach, duodenum | Tracheal aspirate | Bone marrow, lung, rectum, BAL, CSF | NT |
| Positive biopsy sites | Vastus lateralis | Vastus lateralis | Quadriceps femoris** | Deltoid, tongue | Deltoid |
| A. algerae sequence | Yes | Yes | Yes | Yes | Yes |
| Immunosuppression reduced | Yes | Yes | Yes | Yes | Yes |
| Albendazole | Yes | No | Yes | No | Yes |
| Outcome | Survived >18 mo | Died, aspiration pneumonia | Died, stroke | Died, palliated | Died, aspiration pneumonia |
*ND, not described in publication; CK, creatinine kinase; ALT, alanine transaminase; AST, aspartate transaminase; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; EMG, electromyography; NT, not tested; CSF, cerebrospinal fluid; BAL, bronchoalveolar lavage. †Biochemical and hematologic values are from the most recent visit to hospital, unless otherwise indicated. Reference values are in parentheses. ‡Anemia was normocytic. §Case-patient A: serum creatinine was higher (150 μmol/L) at the first admission; case-patient B: baseline creatinine was ≈160μμmol/L; case-patient 3: preexisting renal impairment, with transplant. ¶Case-patient A: urinary myoglobin was negative; case-patient B urinary albumin:creatinine ratio 8 mo previously was normal; case-patient 3: urinary protein 2 mo previously was 0.68 g/24 h. #Modified trichrome stain on concentrated feces. **Component of quadriceps femoris not specified in publication.