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The type 2 diabetic group treated with memantine alone shows some protective effect for the drug in the form of: ( a): preservation of small pyramidal cells except for deepest layer (↑) with clumping of neuronal fibrils (f); but with ( b): shrinkage and darkening of many large pyramidal cells and ( c): clumping & disorganization of granular cells with dilated vessels (v) and normal glial cells (*) in molecular layer. (H & E ×400).
