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Cbl-family targets in T cell activation. Following T cell activation, Cbl E3 ligases ubiquitinate subunits of the TCR as well as phosphorylated signaling components including ZAP70, the p85 subunit of PI3Kinase, Fyn, Lck and Vav [38–40, 74–78]. This ubiquitination results in dampening of T cell activation signals. P, phosphorylation; Ca++, calcium ions
