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. Author manuscript; available in PMC: 2014 Jan 24.
Published in final edited form as: Brain Res. 2006 Feb 20;1091(1):243–254. doi: 10.1016/j.brainres.2006.01.040

Fig. 2.

Fig. 2

Cre activity in the CreERT2 fusion protein is inducible by 4-OH-tamoxifen. In the absence of tamoxifen, CreER is bound to Hsp90 and located in the cytoplasm. Tamoxifen preferentially binds to the Estrogen Receptor (ER), displacing Hsp90 and inducing translocation of CreER to the nucleus, hence activating Cre.