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. Author manuscript; available in PMC: 2014 Jan 24.
Published in final edited form as: Brain Res. 2006 Feb 20;1091(1):243–254. doi: 10.1016/j.brainres.2006.01.040

Fig. 3.

Fig. 3

Inducible regulation of GOI or Cre by tetracycline. (A) The TetON system utilizes rtetR to regulate gene expression. In the absence of antibiotic, the rtTA protein is unable to bind to the TRE, but with the addition of tetracycline or doxycycline rtTA, it now promotes the expression of the GOI or Cre. (B) In the TetOFF system, the rTA is a normal-bound TRE and drives Cre or GOI transcription. When antibiotic is provided, the rTA is no longer able to bind to TRE, causing a cessation of transcription.