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. Author manuscript; available in PMC: 2014 Jan 24.
Published in final edited form as: Adv Exp Med Biol. 2013;786:329–351. doi: 10.1007/978-94-007-6621-1_18

Fig. 18.3. Functions of miRNAs in cellular reprogramming.

Fig. 18.3

(a) Overview of the effects of miRNAs on iPSC formation. miRNAs beneficial for iPSC induction are represented in red while miRNAs shown to repress iPSC formation are in green. In orange are the microRNAs whose function has not been tested yet during reprogramming of somatic cells into pluripotent stem cells. (b) Mechanisms of action of miRNAs during the reprogramming process. OSK: Oct4, Sox2, Nanog. MET mesenchymal to epithelial transition