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. 2013 Aug 15;6(8):1146–1159. doi: 10.1111/eva.12092

Figure 7.

Figure 7

Effect of therapies that target growth factors. Reducing the amount of available growth factor increases the threshold from h1 = 0.3 to h2. d = 3, h1 = 0.3, c = 0.01, s = 20. In all cases, the shift from h1 to h2 occurs gradually, after 1000 generations per cell, in 100 generations.