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. Author manuscript; available in PMC: 2014 Jan 24.
Published in final edited form as: Glia. 2012 Jul 31;60(11):1761–1772. doi: 10.1002/glia.22395

Figure 1. GABAA receptor activation induced astrocyte Vm depolarization in gramicidin.

Figure 1

A. A mature astrocyte characterized by its passive membrane conductance that was induced by the voltage commands shown in the inset below the recording; the cell was held at −80 mV at resting and stepped to command voltages of −160 to 20 mV in 10 mV increment. B. The current-to-voltage (I-V) relationship of this the same cell. C, E. A 2-min application of 0.3 mM GABA or 0.1 mM THIP induced Vm depolarization in astrocytes that could be substantially (D) or completely (F) inhibited by 0.01 mM SR95531.