Table 1.

Alignment of the core region of DQ2-restricted and DQ8-restricted gluten epitopes.

HLA restriction	Epitope	Peptide-binding register, P1–P9									Present in the 33mer	Reference
		1	2	3	4	5	6	7	8	9
DQ2	avenin	P	Y	P	E	Q	E	E	P	F		[39]
	gliadin-α-I	P	F	P	Q	P	E	L	P	Y	✓	[34]
	gliadin-α-III	P	Y	P	Q	P	E	L	P	Y	✓	[35]
	gliadin-α-II	P	Q	P	E	L	P	Y	P	Q	✓	[34]
	gliadin-γ-I	P	Q	Q	S	F	P	E	Q	Q		[33]
	gliadin-γ-II	I	Q	P	E	Q	P	A	Q	L		[37]
	gliadin-γ-VI	Q	Q	P	F	P	E	Q	P	Q		[36]
	gliadin-γ-IV	S	Q	P	E	Q	E	F	P	Q		[35]
	gliadin-γ-VII	P	Q	P	E	Q	E	F	P	Q		[36]
	gliadin-γ-III	Q	Q	P	E	Q	P	Y	P	Q		[35]
	gliadin-γ-VII	Q	Q	P	E	Q	P	F	P	Q		[36]
	gliadin-α20	F	R	P	E	Q	P	Y	P	Q		[37]
	glutenin-17	P	F	S	E	Q	E	Q	P	V		[37]
DQ8	gliadin-γ-I	E	Q	P	Q	Q	P	F	P	Q		[41]
	gliadin-γ-I	E	Q	P	Q	Q	P	Y	P	E		[41]
	gliadin-α-I	E	G	S	F	Q	P	S	Q	E		[40]
	glutenin	E	G	Y	Y	P	T	S	P	E		[38]

Glutamate residues formed by TG2-mediated deamidation that are important for recognition by DQ2-restricted or DQ8-restricted T cells are shown in bold. Additional glutamine residues also targeted by TG2 are underlined.