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ErbB4 isoforms and constructs. A, ErbB4 splicing and cleavage. Alternative splicing to produce JM-A, JM-B, CYT-1, and CYT-2. Metalloproteinase cleavage of the JM-A stalk releases m80, and then γ-secretase frees s80. S, stalk; T, transmembrane domain; B, BH3 domain; Z, PDZ binding site; N, functionally important nuclear localization signal; X, WW-binding PPXY domain. B, the ErbB4 constructs described in the text.
