Table 3. Cox multivariate analyses of prognostic factors on patients' survival.

Variables	Hazard ratio	95% CI	P value
Cancer-specific survival *
AFP, ng/ml (≤20v >20)	2.498	1.619– 3.855	<0.001
Tumor size, cm (≤5v >5)	1.516	1.021– 2.249	0.039
Tumor multiplicity (single v multiple)	1.760	1.182– 2.621	0.005
Stage (I-II v III-IV)	1.217	0.752– 1.969	0.424
Vascular invasion (absent v present)	1.929	1.197– 3.107	0.007
PTPN12 expression (decreased v normal)	0.353	0.226– 0.552	<0.001
Recurrence-free survival†
AFP, ng/ml (≤20v >20)	2.481	1.601– 3.845	<0.001
Tumor size, cm (≤5v >5)	1.507	1.012– 2.243	0.043
Tumor multiplicity (single v multiple)	1.761	1.182– 2.623	0.005
Tumor differentiation (I-II v III-IV)	1.045	0.711– 1.536	0.823
Stage (I-II v III-IV)	1.218	0.752– 1.972	0.422
Vascular invasion (absent v present)	1.916	1.184– 3.100	0.008
PTPN12 expression (decreased v normal)	0.352	0.225– 0.551	<0.001

^*The total number of patients and total number of events in this model were 248 and 112, respectively; ^†The total number of patients and total number of events in this model were 248 and 148, respectively; CI, confidence interval; AFP, alpha-fetoprotein.