Table 3. Analysis of overall survival.

				Univariate analysis			Cox Regression analysis3
Factor	n	%	% Dead	10 Years survival rate (%) [95% CI1]		p-value2	Hazard Ratio [95%-CI1]		p-value
All patients	437	100.0	11.9	86.2	[82.5; 89.9]
Gender						0.484
Male	229	52.4	13.1	85.4	[80.1; 90.7]
Female	208	47.6	10.6	89.4	[84.9; 93.9]
Age						0.199
<50 years	131	30.0	9.9	88.4	[81.9; 94.8]
50–59 years	107	24.5	12.1	86.6	[79.7; 93.5]
60–69 years	115	26.3	11.3	87.7	[80.8; 94.5]
≥70 years	84	19.2	15.5	78.2	[62.9; 93.4]
BRAF -V600 Mutations						0.119
Wildtype	268	61.3	9.7	89.8	[85.9; 93.7]
V600 Mutation	169	38.7	15.4	80.9	[73.6; 88.2]
Ulceration						<0.001
Not ulcerated	391	89.5	7.2	91.3	[87.8; 94.8]		1
Ulcerated	46	10.5	52.2	45.1	[29.8; 60.4]		3.6	[1.9; 6.9]	<0.001
Histopathologic subtype						<0.001
SSM	328	75.2	8.8	89.9	[86.2; 93.6]
Nodular	26	6.0	42.3	52.3	[30.9; 73.7]
LMM	52	11.9	5.8	91.5	[81.7; 100.0]
ALM	30	6.9	26.7	70	[49.0; 91.0]
Missing data	1
Clark level						<0.001
Level I–III	243	55.6	5.8	93.3	[89.4; 97.2]
Level IV–V	194	44.4	19.6	77.5	[70.8; 84.2]
Tumor thickness primary						<0.001
≤1.00 mm	239	54.7	2.9	95.6	[91.9; 99.3]		1
1.01–2.00 mm	137	31.4	13.9	84.6	[77.7; 91.5]		1.9	[0.7; 5.4]	0.236
2.01–4.00 mm	45	10.3	40.0	56.6	[40.5; 72.7]		4.6	[1.4; 14.5]	0.010
>4.00 mm	16	3.7	50.0	42.9	[15.3; 70.5]		4.7	[1.1; 19.6]	0.035
Mitoses/mm 2						<0.001
<1	217	50.1	2.8	96.5	[93.3; 99.7]		1
≥1	216	49.9	20.8	76.5	[69.9; 83.0]		2.9	[1.1; 7.6]	0.028
Missing data	4

¹95%-CI = 95% confidence interval;

²p-values are results of log rank tests excluding cases with missing values.

³Cox Regression analysis was performed in 430 patients.

4 Patients had unknown mitotic rate and in 3 cases censoring occurred before the first event was observed; the model was adjusted for the confounding effects of age, gender, histological subtype, BRAF-V600 mutations, and Clark's level of invasion.