Table 1. Summary of associations between 11 SNPs in miR-101 and breast cancer risk.
SNP | Chr | Position | Location | Allelesa | Caseb | Controlb | Call rate | MAFc | HWEd | OR(95% CI)e | P valuee |
N = 1064 | N = 1073 | (%) | (case/control) | ||||||||
rs7536540 | 1p31.3 | 65,524,582 | hsa-mir-101-1 | G/C | 338/528/197 | 351/510/211 | 97.94 | 0.434/0.435 | 0.291 | 0.998(0.881–1.131) | 0.982 |
rs1011210 | 1p31.3 | 65,526,176 | hsa-mir-101-1 | A/G | 405/516/133 | 442/466/159 | 97.19 | 0.371/0.367 | 0.048 | – | – |
rs555146 | 1p31.3 | 65,527,407 | hsa-mir-101-1 | C/A | 838/205/20 | 832/218/23 | 97.94 | 0.115/0.123 | 0.064 | 0.930(0.772–1.121) | 0.446 |
rs578481 | 1p31.3 | 65,528,755 | hsa-mir-101-1 | A/G | 507/460/97 | 535/436/101 | 97.99 | 0.307/0.298 | 0.381 | 1.042(0.910–1.192) | 0.552 |
rs705509 | 1p31.3 | 65,531,751 | hsa-mir-101-1 | G/A | 326/512/216 | 339/510/220 | 97.33 | 0.448/0.444 | 0.293 | 1.034(0.914–1.171) | 0.594 |
rs462480 | 9p24.1 | 4,850,436 | hsa-mir-101-2 | A/C | 531/442/88 | 591/395/86 | 97.80 | 0.291/0.265 | 0.084 | 1.182(1.030–1.357) | 0.017 |
rs17718377 | 9p24.1 | 4,854,472 | hsa-mir-101-2 | G/C | 821/227/13 | 845/218/10 | 97.85 | 0.119/0.111 | 0.437 | 1.113(0.914–1.356) | 0.287 |
rs4742051 | 9p24.1 | 4,858,997 | hsa-mir-101-2 | A/G | 576/412/74 | 618/386/68 | 97.85 | 0.264/0.244 | 0.456 | 1.139(0.988–1.314) | 0.074 |
rs1537146 | 9p24.1 | 4,859,303 | hsa-mir-101-2 | A/G | 623/388/51 | 655/361/57 | 97.89 | 0.231/0.222 | 0.426 | 1.081(0.931–1.255) | 0.308 |
rs10974820 | 9p24.1 | 4,859,872 | hsa-mir-101-2 | G/A | 875/180/8 | 905/162/5 | 97.89 | 0.092/0.080 | 0.538 | 1.174(0.938–1.469) | 0.162 |
rs1053872 | 9p24.1 | 4,860,643 | hsa-mir-101-2 | C/G | 265/532/265 | 305/541/226 | 97.85 | 0.500/0.463 | 0.667 | 1.179(1.040–1.337) | 0.010 |
Major/minor allele;
Major homozygote/heterozygote/rare homozygote between cases and controls;
Minor allele frequency (MAF);
P values for Hardy-Weiberger equilibrium (HWE) tests;
Logistic regression with adjustment for age, age at menarche and menopausal status in additive model.