Table 2. Cumulative effect of rs462480 and rs1053872 in the flanking region of miR-101-2 on breast cancer risk.
| No. of risk allelea | Cases | Controls | OR(95%CI)b | P b |
| N (%) | N (%) | |||
| 0 | 251(23.70) | 291(27.12) | 1 | |
| 1 | 234(22.10) | 258(24.04) | 1.03(0.80–1.33) | 0.815 |
| 2 | 356(33.62) | 346(32.25) | 1.22(0.97–1.54) | 0.096 |
| 3–4 | 218(20.59) | 178(16.59) | 1.48(1.13–1.94) | 0.005 |
| Trend | 0.002 | |||
| Binary classification | ||||
| 0–1 | 485(45.80) | 549(51.20) | 1 | |
| 2–4 | 574(54.20) | 523(48.80) | 1.29(1.08–1.54) | 0.005 |
a
The rs462480 C allele and rs1053872 G allele were assumed as risk alleles based on main effect of individual locus;
b
Adjusted for age, age at menarche, menopausal status.