Table 3. Stratification analysis on the association of rs462480 and rs1053872 in the flanking region of miR-101-2 with breast cancer risk.
| Characteristics | Case N(%) | Control N(%) | OR(95%CI)c | P c | P d | ||
| 0a | 1b | 0a | 1b | ||||
| Age | |||||||
| <51 | 280(47.6) | 308(52.4) | 275(50.8) | 266(49.2) | 1.19(0.93,1.52) | 0.16 | 0.317 |
| ≥51 | 205(43.5) | 266(56.5) | 274(51.6) | 257(48.4) | 1.43(1.10,1.86) | 0.006 | |
| Menopausal status | |||||||
| Premenopausal | 242(47.3) | 270(52.7) | 255(50.6) | 249(49.4) | 1.14(0.89,1.47) | 0.305 | 0.148 |
| Postmenopausal | 193(42.9) | 257(57.1) | 275(52.5) | 249(47.5) | 1.49(1.15,1.94) | 0.003 | |
| Age at menarche | |||||||
| <16 | 272(45.5) | 326(54.5) | 224(54.5) | 187(45.5) | 1.43(1.11,1.85) | 0.005 | 0.225 |
| ≥16 | 205(46.3) | 238(53.7) | 323(49.0) | 336(51.0) | 1.15(0.90,1.46) | 0.275 | |
| Age at first live birth | |||||||
| <24 | 116(48.5) | 123(51.5) | 184(49.7) | 186(50.3) | 1.09(0.78,1.51) | 0.617 | 0.259 |
| ≥24 | 339(45.0) | 415(55.0) | 351(52.3) | 320(47.7) | 1.37(1.10,1.71) | 0.005 | |
| ER status | |||||||
| Positive | 234(48.1) | 253(52.0) | 1.17(0.94,1.46) | 0.17 | 0.557 | ||
| Negative | 173(45.9) | 204(54.1) | 1.29(1.02,1.65) | 0.038 | |||
| PR status | |||||||
| Positive | 245(48.6) | 259(51.4) | 1.14(0.92,1.42) | 0.24 | 0.357 | ||
| Negative | 162(45.0) | 198(55.0) | 1.33(1.04,1.70) | 0.024 | |||
a
Subjects with 0–1 risk allele of rs462480 and rs1053872;
b
Subjects with 2–4 risk alleles of rs462480 and rs1053872;
c
Derived from logistic regression with an adjustment for age, age at menarche and menopausal status;
d
P for heterogeneity test.