Table 3. Association of the IFN-γ SNPs with risk of sepsis.
Sepsis (%) | Control (%) | OR(95%CI) | P value | r2 | ||
−1616T/C | +874 A/T | |||||
−1616 T/C | ||||||
CC | 83 (42.3) | 121 (56.8) | 1.00 (reference) | |||
TC | 98 (50.0) | 74 (34.7) | 1.99 (1.31–3.01) | |||
TT | 15 (7.7) | 18 (8.5) | 1.22 (0.58–2.57) | 0.0045 | ||
TC+TT | 113 (57.7) | 92 (43.2) | 1.84 (1.24–2.73) | 0.0024 | ||
C | 264 (67.3) | 316 (74.2) | 1.00 (reference) | |||
T | 128 (32.7) | 110 (25.8) | 0.72 (0.53–0.97) | 0.032 | ||
+874 A/T | 0.52 | |||||
TT | 116 (59.2) | 150 (70.4) | 1.00 (reference) | |||
TA | 71 (36.2) | 56 (26.3) | 1.68 (1.09–2.58) | |||
AA | 9 (4.6) | 7 (3.3) | 1.70 (0.61–4.78) | 0.046 | ||
TA+AA | 80 (40.8) | 63 (29.6) | 1.68 (1.11–2.54) | 0.013 | ||
T | 303 (77.3) | 356 (83.6) | 1.00 (reference) | |||
A | 89 (22.7) | 70 (16.4) | 1.49 (1.05–2.12) | 0.024 | ||
+3234 C/T | 0.595 | 0.894 | ||||
TT | 117 (69.7) | 145 (68.1) | 1.00 (reference) | |||
TC | 71 (36.2) | 60 (28.2) | 1.49 (0.97–2.27) | |||
CC | 8 (4.1) | 8 (3.8) | 1.26 (0.45–3.50) | 0.18 | ||
TC+CC | 79 (40.3) | 68 (32.0) | 1.46 (0.97–2.20) | 0.067 | ||
T | 305 (77.8) | 350 (82.2) | 1.00 (reference) | |||
C | 87 (22.2) | 76 (17.8) | 1.31 (0.93–1.85) | 0.2 | ||
Haplotype | ||||||
C T T | 262 (66.8) | 311.85 (73.2) | 0.66 (0.49–0.90) | 0.009 | ||
T A C | 87 (22.2) | 65.85 (15.5) | 1.51 (1.06–2.16) | 0.022 | ||
T T T | 41 (10.5) | 35.09 (8.2) | 1.27 (0.79–2.03) | 0.33 |
Values in bold and underline indicate statistical significance.