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. 2014 Jan 24;9(1):e87049. doi: 10.1371/journal.pone.0087049

Table 3. Association of the IFN-γ SNPs with risk of sepsis.

Sepsis (%) Control (%) OR(95%CI) P value r2
−1616T/C +874 A/T
−1616 T/C
CC 83 (42.3) 121 (56.8) 1.00 (reference)
TC 98 (50.0) 74 (34.7) 1.99 (1.31–3.01)
TT 15 (7.7) 18 (8.5) 1.22 (0.58–2.57) 0.0045
TC+TT 113 (57.7) 92 (43.2) 1.84 (1.24–2.73) 0.0024
C 264 (67.3) 316 (74.2) 1.00 (reference)
T 128 (32.7) 110 (25.8) 0.72 (0.53–0.97) 0.032
+874 A/T 0.52
TT 116 (59.2) 150 (70.4) 1.00 (reference)
TA 71 (36.2) 56 (26.3) 1.68 (1.09–2.58)
AA 9 (4.6) 7 (3.3) 1.70 (0.61–4.78) 0.046
TA+AA 80 (40.8) 63 (29.6) 1.68 (1.11–2.54) 0.013
T 303 (77.3) 356 (83.6) 1.00 (reference)
A 89 (22.7) 70 (16.4) 1.49 (1.05–2.12) 0.024
+3234 C/T 0.595 0.894
TT 117 (69.7) 145 (68.1) 1.00 (reference)
TC 71 (36.2) 60 (28.2) 1.49 (0.97–2.27)
CC 8 (4.1) 8 (3.8) 1.26 (0.45–3.50) 0.18
TC+CC 79 (40.3) 68 (32.0) 1.46 (0.97–2.20) 0.067
T 305 (77.8) 350 (82.2) 1.00 (reference)
C 87 (22.2) 76 (17.8) 1.31 (0.93–1.85) 0.2
Haplotype
C T T 262 (66.8) 311.85 (73.2) 0.66 (0.49–0.90) 0.009
T A C 87 (22.2) 65.85 (15.5) 1.51 (1.06–2.16) 0.022
T T T 41 (10.5) 35.09 (8.2) 1.27 (0.79–2.03) 0.33

Values in bold and underline indicate statistical significance.