Table 4. Combination analysis of the IFN-γ SNPs and sepsis development by clinical grouping.
| Sepsis(%) | Severesepsis (%) | OR(95%CL) | Pvalue | APACHE < = 20 (%) | APACHE >20 (%) | OR(95%CL) | Pvalue | SOFA < = 10 (%) | SOFA >10 (%) | OR(95%CL) | Pvalue | Discharged (%) | Death(%) | OR(95%CL) | P value | |
| −1616 T/C | ||||||||||||||||
| CC | 36 (40.5) | 47 (43.9) | 1.00 (reference) | 41 (44.1) | 42 (41.2) | 1.00 (reference) | 45 (43.3) | 38 (41.3) | 1.00 (reference) | 41 (37.6) | 42 (48.3%) | 1.00 (reference) | ||||
| TC | 39 (43.8) | 59 (55.1) | 1.25 (0.67–2.34) | 38 (40.9) | 60 (58.8) | 1.65 (0.88–3.10) | 45 (43.3) | 53 (57.6) | 1.39 (0.77–2.54) | 60 (55.1) | 38 (43.7%) | 0.68 (0.37–1.25) | ||||
| TT | 14 (15.7) | 1 (0.9) | 0.06 (0.01–0.50) | <0.001 | 15 (16) | 0 | NA | <0.0001 | 14 (13.5) | 1 (1.1) | 0.09 (0.01–0.75) | 0.001 | 8 (7.3) | 7 (8.3) | 0.98 (0.31–3.07) | 0.44 |
| TC+TT | 53 (59.5) | 60 (56.1) | 0.94 (0.51–1.72) | 0.84 | 53 (56.4) | 60 (58.8) | 1.18 (0.65–2.16) | 0.58 | 59 (56.7) | 54 (58.7) | 1.10 (0.61–1.97) | 0.75 | 68 (62.4) | 42 (50) | 0.72 (0.40–1.29) | 0.27 |
| C | 111 (62.4) | 153 (71.5) | 1.00 (reference) | 120 (63.8) | 144 (70.6) | 1.00 (reference) | 135 (64.9) | 129 (70.1) | 1.00 (reference) | 142 (65.1) | 122 (70.1) | 1.00 (reference) | ||||
| T | 67 (37.6) | 61 (28.5) | 1.51 (0.99–2.31) | 0.05 | 68 (36.2) | 60 (29.4) | 1.36 (0.89–2.07) | 73 (35.1) | 55 (29.9) | 1.27 (0.83–1.94) | 0.27 | 76 (34.9) | 52 (29.9) | 1.26 (0.82–1.93) | 0.3 | |
| +874 A/T | ||||||||||||||||
| TT | 47 (52.8) | 69 (64.5) | 1.00 (reference) | 55 (58.5) | 61 (59.8) | 1.00 (reference) | 62 (59.6) | 54 (58.7) | 1.00 (reference) | 58 (53.2) | 58 (66.7) | 1.00 (reference) | ||||
| TA | 34 (38.2) | 37 (34.6) | 0.77 (0.41–1.43) | 30 (31.9) | 41 (40.2) | 1.28 (0.68–2.38) | 33 (31.7) | 38 (41.3) | 1.30 (0.71–2.38) | 45 (41.3) | 26 (29.9) | 0.63 (0.34–1.18) | ||||
| AA | 8 (9) | 1 (0.9) | 0.19 (0.02–1.66) | 0.18 | 9 (9.6) | 0 (0) | NA | 0.012 | 9 (8.7) | 0 (0) | NA | 0.005 | 6 (5.5) | 3 (3.4) | 1.45 (0.31–6.79) | 0.35 |
| TA+AA | 42 (47.2) | 38 (35.5) | 0.70 (0.38–1.29) | 0.25 | 39 (41.5) | 41 (40.2) | 1.08 (0.59–2.00) | 0.8 | 42 (40.4) | 38 (41.3) | 1.09 (0.60–1.97) | 0.77 | 51 (46.8) | 29 (33.3) | 0.65 (0.36–1.19) | 0.16 |
| A | 50 (28.1) | 39 (18.2) | 1.00 (reference) | 48 (25.5) | 41 (20.1) | 1.00 (reference) | 51 (24.5) | 38 (20.7) | 1.00 (reference) | 57 (26.1) | 32 (18.4) | 1.00 (reference) | ||||
| T | 128 (71.9) | 175 (81.8) | 0.57 (0.35–0.91) | 0.02 | 140 (74.5) | 163 (79.9) | 0.73 (0.46–1.19) | 0.2 | 157 (75.5) | 146 (79.3) | 0.80 (0.50–1.29) | 0.36 | 161 (73.9) | 142 (81.6) | 0.64 (0.39–1.04) | 0.07 |
| +3234 C/T | ||||||||||||||||
| TT | 48 (53.9) | 69 (64.5) | 1.00 (reference) | 56 (59.6) | 61 (59.8) | 1.00 (reference) | 63 (60.6) | 54 (58.7) | 1.00 (reference) | 59 (54.1) | 58 (66.7) | 1.00 (reference) | ||||
| TC | 34 (38.2) | 37 (34.6) | 0.78 (0.42–1.45) | 30 (31.9) | 41 (40.2) | 1.30 (0.70–2.42) | 33 (31.7) | 38 (41.3) | 1.33 (0.73–2.42) | 45 (41.3) | 26 (29.9) | 0.64 (0.35–1.20) | ||||
| CC | 7 (7.9) | 1 (0.9) | 0.22 (0.02–2.01) | 0.27 | 8 (8.5) | 0 (0) | NA | 0.02 | 8 (7.7) | 0 (0) | NA | 0.009 | 5 (4.6) | 3 (3.6) | 1.07 (0.22–5.15) | 0.36 |
| TC+CC | 41 (46.1) | 38 (35.5) | 0.72 (0.39–1.33) | 0.3 | 38 (40.4) | 41 (40.2) | 1.12 (0.61–2.06) | 0.72 | 41 (39.4) | 38 (41.3) | 0.79 (0.41–1.51) | 0.81 | 50 (45.9) | 29 (33.3) | 0.67 (0.37–1.23) | 0.20 |
| T | 130 (73.0) | 175 (81.8) | 1.00 (reference) | 142 (75.5) | 163 (79.9) | 1.00 (reference) | 159 (76.4) | 146 (79.3) | 1.00 (reference) | 163 (74.8) | 142 (81.6) | 1.00 (reference) | ||||
| C | 48 (27.0) | 39 (18.2) | 0.60 (0.37–0.98) | 0.04 | 46 (24.5) | 41 (20.1) | 0.78 (0.48–1.25) | 0.3 | 49 (23.6) | 38 (20.7) | 0.84 (0.52–1.36) | 0.49 | 55 (25.2) | 32 (18.4) | 0.67 (0.41–1.09) | 0.11 |
| Haplotype | ||||||||||||||||
| C T T | 111 (61.7) | 153 (71.5) | 1.51 (0.99–2.31) | 0.054 | 120 (63.2) | 144 (70.6) | 1.36 (0.89–2.08) | 0.154 | 135 (64.3) | 129 (70.1) | 1.27 (0.83–1.94) | 0.273 | 139 (63.8) | 125 (71.8) | 1.32 (0.86–2.04) | 0.202 |
| T A C | 48 (26.7) | 39 (18.2) | 0.60 (0.37–0.98) | 0.038 | 46 (24.2) | 41 (20.1) | 0.78 (0.48–1.25) | 0.298 | 49 (23.3) | 38 (20.7) | 0.85 (0.52–1.36) | 0.489 | 56 (25.7) | 31 (17.8) | 0.68 (0.41–1.11) | 0.122 |
| T T T | 19 (10.6) | 22 (10.3) | 0.96 (0.50–1.84) | 0.899 | 22 (11.6) | 19 (9.3) | 0.78 (0.41–1.48) | 0.44 | 24 (11.4) | 17 (9.2) | 0.78 (0.41–1.50) | 0.458 | 23 (10.5) | 18 (10.4) | 1.05 (0.55–2.01) | 0.886 |
Values in bold and underline indicate statistical significance.