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. 2014 Jan 24;9(1):e86881. doi: 10.1371/journal.pone.0086881

Figure 2. Compound C diminishes LPS induced AMPK activation.

Figure 2

A. RAW 264.7 cells were pretreated with vehicle or 10 µM compound C (CC) for 15 min, prior to 1 µg/mL LPS challenge. After different time points of LPS challenge, expression of pAMPKα1 and pACC was determined by western blot. B. RAW 264.7 cells were treated with vehicle, 1 mM AICAR, 10 µM compound C (CC), or combination of AICAR and compound C for 15 min, followed by 1 µg/mL LPS treatment for 60 min. Expression of pAMPKα1 and pACC was determined by western blot. Data are represented three to four independent experiments.