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. 2014 Jan 24;9(1):e87119. doi: 10.1371/journal.pone.0087119

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© 2014 Howitt et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Quantification of neuromelanin levels from the substantia nigra of control and PD brains showed a significant decrease in PD, indicating a loss of dopaminergic neurons. (B) Ndfip1 is expressed (arrows) in some but not all dopaminergic neurons of the substantia nigra (brown pigment represents neuromelanin). (C) High power image of Ndfip1 staining of dopaminergic neurons showed a predominant cytoplasmic distribution. Asterisks in B and C show dopaminergic neurons with no Ndfip1 staining. (D) Quantification of Ndfip1 positive dopaminergic neurons of the substantia nigra showed no significant difference between control and PD brains. (E) DMT1 is expressed in the cytoplasm (arrows) of dopaminergic neurons of the substantia nigra. Scale bars: 100 µm (B, E), 25 µm (C). (A, D) Values are the mean ±SD, * p<0.05 Mann Whitney U tests.