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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Alcohol Clin Exp Res. 2012 Nov 16;37(4):655–662. doi: 10.1111/acer.12009

Figure 1. The α5 subunit plays an important role for sedative dose of ethanol and influences ethanol-induced ataxia.

Figure 1

(A) The loss of righting reflex (LORR) duration for 3.2g/kg (i.p.) ethanol was shorter for α5+/+ (black) compared to α5−/− (gray) mice. (B) On the accelerating rotarod, α5−/−(gray) had an increased latency to fall compared to α5+/+ (black) mice for 2 g/kg (i.p.) ethanol dose. In A, n=8–13 animals, B, n=11 animals. The values are expressed as duration (mins) ± SEM (A) and duration (secs) ± SEM (B) (two-tailed unpaired t-test (A) and two-way ANOVA (B) followed by Newman-Keuls test, *p<0.05).