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. Author manuscript; available in PMC: 2014 Dec 23.
Published in final edited form as: ACS Nano. 2013 Nov 20;7(12):10597–10611. doi: 10.1021/nn404719c

Figure 2. Comparative endocytosis of carriers targeted to ICAM-1 vs. M6PR.

Figure 2

(A) Endocytosis of 1-μm carriers coated with anti-M6PR after incubation for 30 min at 37°C with activated HUVECs, compared to anti-ICAM carriers or control IgG carriers. Phase contrast (top panels) shows total carriers bound and internalized. Fluorescence images (bottom panels) show surface-bound, non-internalized carriers. Arrowheads mark non-internalized carriers and arrows mark endocytosed ones. Scale bar = 10 μm. (B) Low, although specific, internalization of anti-M6PR carriers compared to anti-ICAM carriers and control IgG carriers, quantified as in (A). Mean ± standard error of the mean. *Compared to anti-ICAM carriers; #compared to IgG carriers (p< 0.05).