Table 4.

In Vivo Confocal Microscopy Features by Disease Group, Based on Masked Grading

IVCM Features	Controls	Benign Cases∗	OSSN Cases	P Value†	P Value‡
	N/57 (%)	N/18 (%)	N/26 (%)
Hyper-reflective cells				<0.001	0.9
None	54 (94.7%)	7 (38.3%)	12 (46.1%)
<50%	3 (5.3%)	7 (38.8%)	8 (30.7%)
>50%	0 (0.0%)	4 (22.2%)	6 (23.1%)
Variation in cell size				<0.001	0.5
Uniform	55 (96.4%)	9 (50%)	17 (65.3%)
Mild	1 (1.7%)	6 (33.3%)	4 (15.3%)
Marked	1 (1.7%)	3 (16.7%)	5 (19.2%)
Starry night appearance of basal cells				0.001	0.8
Nil	57 (100%)	14 (77.7%)	22 (84.6%)
Few to many	0 (0.0%)	2 (11.1%)	1 (3.8%)
Amorphous material	0 (0.0%)	2 (11.1%)	3 (11.5%)

IVCM = in vivo confocal microscopy; OSSN = ocular surface squamous neoplasia.

^∗Including 1 lymphoma case.

^†P value is for the comparison of normal controls with all cases (benign and malignant combined) by Fisher exact test.

^‡P value is for the comparison of benign with malignant cases, by Fisher exact test.