Table 1.
Plasma and brain levels of rifampicin and caffeine after 3 h washout period, and Kp values in C57BL/6 wild-type male mice (n =12 for each treatment group)
| Group | Drug concentration (µg/ml) |
Kp | |
|---|---|---|---|
| Plasma | Brain | ||
| Rifampicin | 7.4± 3.9 | 0.15 ± 0.08 | 0.03 |
| Caffeine | 20 ± 5.4 | 11.8 ± 3.6 | 0.5 |