Table 3.
RNA editing of AMPA receptors in the postmortem brains of patients with mental disorders
| |
R/G sites |
|
|
|
|
|
Q/R sites |
|---|---|---|---|---|---|---|---|
| GRIA2 flip | GRIA2 flop | GRIA3 flip | GRIA3 flop | GRIA4 flip | GRIA4 flop | GRIA2 | |
| Bipolar disorder |
64.4 ± 16.4 |
54.4 ± 12.5 |
66.3 ± 9.5 |
79.4 ± 10.6 |
56.0 ± 17.1 |
64.8 ± 15.8 |
96.6 ± 3.4 |
| Depression |
62.5 ± 13.8 |
54.9 ± 5.3 |
61.9 ± 9.6 |
82.6 ± 7.7 |
55.0 ± 15.8 |
69.9 ± 10.7 |
97.6 ± 3.0 |
| Schizophrenia |
66.0 ± 10.8 |
53.7 ± 8.0 |
66.0 ± 5.9 |
83.5 ± 9.4 |
60.5 ± 9.7 |
71.5 ± 6.1 |
99.0 ± 1.9 |
| Control |
70.1 ± 4.8 |
58.1 ± 4.4 |
65.0 ± 12.1 |
85.5 ± 3.5 |
63.2 ± 9.5 |
71.2 ± 7.5 |
98.8 ± 2.3 |
|
r* (GAPDH) |
0.508 |
0.476 |
0.300 |
0.644 |
0.527 |
0.565 |
ns |
| r* (CFL1) | 0.477 | 0.430 | 0.251 | 0.642 | 0.509 | 0.600 | ns |
*r = Correlation coefficient between editing efficiency of AMPA receptors and ADAR2 expression level.