Table 9.
Summary of functional specialization in the central zones of HFPIN
| Percentage of proteins | ||||
|---|---|---|---|---|
| Enriched pathway |
Zone 1 |
Zone 2 |
Zone 3 |
Zone 4 |
| Signal transduction |
38% |
24.8% |
- |
- |
| Immune system |
29.8% |
10.6% |
4.5% |
- |
| Hemostasis |
17% |
5.7% |
2.7% |
- |
| Disease |
16.8% |
8% |
4.1% |
- |
| Gene expression |
8.2% |
8.8% |
9.8% |
- |
| Metabolism |
5.1% |
8.4% |
7.6% |
10.4% |
| Membrane trafficking |
- |
- |
1.2% |
2.8% |
| Neuronal system |
4.8% |
2.5% |
2.3% |
3.3% |
| Transmembrane transport of small molecules | - | 1.9% | 2.4% | 3.6% |