Table 2. Dose Adjustment with Renal Dysfunction.

Visit (Time)	SCr ≤ 2 mg/dl	SCr > 2, but ≤ 3 mg/dl	SCr > 3, but < 5 mg/dl	SCr ≥ 5 mg/dl
0 (Baseline)*	300 mg	100 mg	Excluded	Excluded
1 (7-10 Days)*†	600 mg	300 mg	---	---
2 (4 Weeks)‡	600 mg	300 mg	100 mg	Discontinue
4 (12 Weeks)‡	600 mg	300 mg	100 mg	Discontinue

SCr, serum creatinine level.

^*Screening laboratories used to determine dosing at baseline and visit 1;

^†laboratories are not checked at this visit, which is a telephone call;

^‡if renal function improves at visit 2 or 4, subjects remain at established dose (i.e., no up-titration).