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. 2014 Jan 18;11:7. doi: 10.1186/1743-422X-11-7

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Copyright © 2014 Miller et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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PBMCs from FIV-infected cats display increased surface expression of TGFβ and GARP on CD4⁺CD25⁺lymphocytes and TGFβRII on CD4⁺CD25^-lymphocytes. PBMCs from FIV-infected or control cats were analyzed for surface expression of CD4, CD25, TGFβ, GARP and TGFβRII by flow cytometry. Cells were gated on CD4⁺CD25⁺ or CD4⁺CD25^- populations and analyzed for percent expression of A. TGFβ, B. GARP or C. TGFβRII. Box-whisker plots represent the 5^th and 95^th percentiles (whisker), 25^th and 75^th percentiles (box), and median of percent CD4⁺CD25⁺ and CD4⁺CD25^- expression from 6 FIV-positive and 6 FIV-negative cats. Symbols represent individual cats. CD4⁺CD25⁺ cells from FIV⁺ cats exhibit greater surface expression of TGFβ and GARP when compared to CD4⁺CD25⁺ cells from FIV^- cats. CD4⁺CD25^- cells from FIV⁺ cats exhibit greater surface expression of TGFβRII than CD4⁺CD25^- cells from FIV^- cats. (p <0.05, Mann–Whitney test for significance).