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PanIN Lesions. (A) PanIN-1 lesions accumulate mucins, evidenced by Alcian blue staining. (B) H&E stain of human pancreas showing PanIN-1A (arrows) and PanIN-1B (arrowhead) lesions adjacent to a PanIN-2 (boxed). (C) High magnification image of the PanIN-2 lesion in (B) showing luminal budding, and nuclear elongation and loss of polarity.
