Upper Left, Sagittal section of a normal cornea stained with DAPI. Upper Right, The same sagittal section as in A, marked for counting. Keratocyte nuclei were counted by using a manual point and click method. By convention, nuclei were not counted if they crossed the right boundary of the area defined by the yellow box. Lower Left, Sagittal section of a cornea with Fuchs’ endothelial dystrophy. The cornea was edematous with a thickened Descemet membrane. Keratocyte loss was visible in the anterior stroma. Scale bar, 100 μm.