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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: J Investig Med. 2014 Feb;62(2):316–323. doi: 10.231/JIM.0000000000000031

Figure 2.

Figure 2

Mice immunized through TS-exposed buccal mucosa exhibit immunologic tolerance. Each group of mice from an individual experiment demonstrating that TS exposure inhibited induction of CHS was re-immunized 16 days after challenge along with a group of naïve mice (additional positive control) by application of oxazolone to the shaved dorsal skin. A new negative control group consisted of a group of naïve mice mock-immunized by application of vehicle alone to the shaved dorsum. All mice were challenged 5 days later for a CHS response. *p<0.05, **p<0.01, ***p<0.001. N = 20/group from 2 experiments.