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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: J Investig Med. 2014 Feb;62(2):316–323. doi: 10.231/JIM.0000000000000031

Figure 3.

Figure 3

Exposure to TS enhances the growth of an immunogenic tumor in the buccal tissue. Groups of A/J (a) and SCID mice with impaired natural killer cell activity (b) were exposed to TS or room air (mock-smokers) delivered to the nose and mouth over 21 days as described in Materials and Methods. Twenty-four hours later, all mice were injected with viable S1509a tumor cells in the submucosa of the left buccal tissue. Tumor growth was assessed over time by taking the product of two perpendicular diameters as a measure of tumor area. ***p<0.001; NS, not significant. N = 7/group for A/J experiment and N = 11/group for SCID experiment. These experiments are representative of two of each type showing similar results.