Fig. 1.

Weight loss and survival of CAST and BALB/c mice following intranasal infection with VACV WR or ACAM2000. Groups of 4–10, 14–15 weeks old female CAST and 11 weeks old BALB/c mice were infected intranasally with escalating doses of VACV WR or ACAM2000. Animals were monitored daily for weight loss and death for 18 days. Weight loss (A) and survival (C) of CAST mice infected with VACV WR; weight loss (B) and survival (D) of BALB/c mice infected with VACV WR; weight loss of CAST mice (E) and BALB/c mice (F) infected with ACAM2000; virus titers on the day of death in lung, liver, kidney, spleen and brain (G) and ovaries (H) of CAST mice infected with VACV WR. Bars represent standard error of the mean (SEM).