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. Author manuscript; available in PMC: 2014 Jan 26.
Published in final edited form as: Ann N Y Acad Sci. 2008 Nov;1143:61–82. doi: 10.1196/annals.1443.011

Figure 1.

Figure 1

Nomenclature and key structural characteristics of human Siglecs. Although 15 are shown, Siglec-13 is present in nonhuman primates but not in man. V structures indicate the arginine-containing V-set domains with lectin activity; these are followed by C2-type Ig repeat domains. U-shaped structures for Siglec-XII indicate the mutated V-set domains missing arginine that have lost their lectin activity. Also shown is DAP12, illustrated as a shorter transmembrane structure co-associating with Siglec-13, Siglec-14, and Siglec-15. See key for symbols representing cytoplasmic signaling motifs.