Table 2.
The types of abnormal findings and the numbers of rats which showed each abnormity in histopathological examination
| control | LipoTrust | siRNA/LipoTrust | siRNA/LipoTrust + TMZ | TMZ | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
|
|
|||||||||||||||||
| - | ± | + | ++ | - | ± | + | ++ | - | ± | + | ++ | - | ± | + | ++ | - | ± | + | ++ | ||
| Brain | Needle tract | 5 | 3 | 1 | 1 | 4 | 1 | 4 | 5 | ||||||||||||
| Liver | Focal cell infiltration of Glisson’s capsule | 4 | 1 | 4 | 1 | 4 | 5 | 5 | |||||||||||||
| Bile duct proliferation | 5 | 4 | 1 | 5 | 5 | 4 | 1 | ||||||||||||||
| Pancreas | Microvacuolation in secretion | 4 | 1 | 5 | 5 | 5 | 5 | ||||||||||||||
| Kidneys | Eosinophilic body in renal proximal tubular epithelial cells | 2 | 2 | 1 | 2 | 1 | 2 | 1 | 3 | 1 | 2 | 2 | 1 | 2 | 3 | ||||||
| Focal basophilic renal tubule | 4 | 1 | 4 | 1 | 3 | 2 | 3 | 2 | 3 | 2 | |||||||||||
| Vacuolar degeneration of renal proximal tubular cells | 4 | 1 | 5 | 5 | 5 | 5 | |||||||||||||||
| Focal interstitial cell infiltration | 5 | 4 | 1 | 5 | 5 | 5 | |||||||||||||||
| Heart | Focal myocardial degeneration or focal cell accumulation | 5 | 4 | 1 | 5 | 5 | 5 | ||||||||||||||
| Lungs and Bronchi | Focal mineral deposition of artery wall | 4 | 1 | 5 | 4 | 1 | 4 | 1 | 5 | ||||||||||||
| Focal pneumonia | 4 | 1 | 5 | 5 | 5 | 5 | |||||||||||||||
- (normal), ± (minor change), + (mild change), ++ (moderate change). All other tested organs showed only normal findings.