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. 2013 Nov 14;3(1):42–53. doi: 10.5966/sctm.2013-0020

Figure 3.

Figure 3.

ASC-CM suppressed light-induced retinal damage after light exposure. (A): Light-induced retinal degeneration was reduced by ASC-CM. Representative photographs of hematoxylin and eosin staining are as follows: nontreated group (Aa), light exposure (8,000 lx) plus vehicle-treated group (Ab), and light exposure plus ASC-CM-treated (150-fold concentrated, intravitreal administration) group (Ac) at 5 days after light exposure in mice. (Ad): ONL thickness was measured at 5 days after light exposure. The ONL was measured at 240-μm intervals from the optic disc. (B, C): Representative electroretinogram recording in the nontreated group, the light exposure (8,000 lx) plus vehicle-treated group, and the light exposure plus ASC-CM-treated (150-fold concentrated, intravitreal administration) group. Intensity response functions for dark-adapted a-wave (B) and b-wave (C) amplitudes. The ASC-CM-treated group shows significantly preserved a- and b-wave amplitudes compared with the vehicle group. Scale bar = 25 µm. Data are shown as mean ± SEM (normal [nontreated]: n = 13; vehicle: n = 17; ASC-CM: n = 8). *, p < .05 versus the light exposure plus vehicle-treated group (vehicle); **, p < .01. Abbreviations: ASC-CM, adipose-derived stem cell-conditioned medium; ONL, outer nuclear layer.