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. 2014 Jan 27;8:2. doi: 10.3389/fncir.2014.00002

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Copyright © 2014 Ratnadurai-Giridharan, Stefanescu, Khargonekar, Carney and Talathi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–E) Show IIS RMSE with the mean experimental IIS, color coded maps in terms of network parameters and input synchronization (jitter). In each of the colormaps for a fixed input window (τ^SC_Syn), the input percentage from SC to pyramidal cells (f_SC), and the degree of sprouting (P_sprout) was varied. (F) Shows an example model generated IIS in comparison with the mean experimental IIS. (G–I) Shows the input and output rasters and the LFP measured from the activity of the CA1 during low sprouting. The Py cells receive low frequency Poisson input via SC but at 500 ms, there is a quasi-synchronous barrage of input that causes the Py in the CA1 to fire in a synchronous manner. This activity is an example snapshot of the multiple simulations done to create (A–E).