Table 3.
Extracellular vesicle protein levels and BPF
| Model | BPF |
||
|---|---|---|---|
| BPF at baseline n=994 | BPF at follow-up* n=534 | ||
| EV-cystatin C (pg/µg) | I | −0.69 (−0.86–−0.51) | −0.15 (−0.26—−0.04) |
| Mean 10.6 | II | −0.12 (−0.26–0.02) | −0.06 (−0.16–0.04) |
| SD 5.3 | III | −0.11 (−0.24–0.03) | −0.05 (−0.16–0.05) |
| EV-serpin G1 (pg/µg) | I | −0.00 (−0.18–0.17) | 0.04 (−0.05–0.14) |
| Mean 142.2 | II | 0.01 (−0.12–0.14) | 0.02 (−0.06–0.11) |
| SD 85.6 | III | 0.10 (−0.12–0.14) | 0.03 (−0.06–0.11) |
| EV-serpin F2 (pg/µg) | I | 0.05 (−0.12–0.23) | 0.06 (−0.04–0.16) |
| Mean 43.3 | II | −0.10 (−0.23–0.03) | −0.01 (−0.10–0.08) |
| SD 30.4 | III | −0.06 (−0.19–0.07) | 0.01 (−0.09–0.10) |
| EV-CD 14 (pg/µg) | I | −0.45 (−0.62–−0.28) | −0.06 (−0.17–0.05) |
| Mean 12.2 | II | −0.19 (−0.32–−0.06) | −0.05 (−0.15–0.05) |
| SD 3.9 | III | −0.14 (−0.27–−0.01) | −0.03 (−0.13–0.07) |
Bold typeface indicates statistically significant results.
Regression coefficients: increase in BPF (%) per 1SD increase in EV protein level (pg/mL).
Model I: univariable model.
Model II: adjustment for age and gender.
Model III: model II with additional adjustment for systolic blood pressure, pack years smoking and prevalent type 2 diabetes mellitus.
*Models include additional adjustment for baseline WML and follow-up time.
BPF, brain parenchymal fraction; EV, extracellular vesicle; WML, white matter lesion.