Table 4. The parameters of steady-state activation and inactivation of wild-type and SCN5A variants.
WT | N592K (1776C>G) | A551T (1651G>A) | P1090L (3269C>T) | |
---|---|---|---|---|
V0.5, act | −36.3 ± 0.2 | −33.1 ± 0.3** | −38.1 ± 0.2** | −36.8 ± 0.3 |
s, act | 4.1 ± 0.2 | 5.3 ± 0.6 | 3.2 ± 0.2* | 4.5 ± 0.2 |
V0.5, inact | −86.4 ± 0.7 | −85.2 ± 0.9 | −87.8 ± 0.9 | −87.9 ± 0.7 |
s, inact | −7.5 ± 0.6 | −7 ± 0.8 | −7.1 ± 0.8 | −8.6 ± 0.6 |
WT: Wild type; V0.5, act is the half-activation potential and s, act is the slope of the activation curve. V0.5, inact is the half-inactivation potential and s, inact is the slope of the inactivation curve. Data are mean ± SEM and the asterisks indicate the statistical significances by One-way ANOVA with Bonferroni post-hoc test (**P < 0.01; *P < 0.05; n = 4 in wt and 3269C>T and n = 3 in 1776C>G and 1651G>A).