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. 2014 Jan 21;4(1):e003976. doi: 10.1136/bmjopen-2013-003976

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

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Regions of increased radial diffusivity (DR; red) in patients with Parkinson's disease compared with Alzheimer's disease superimposed on the mean fractional anisotropy map from all participants (blue). Significant changes are seen mainly in frontoparietal regions on the left side including parts of the corticospinal tracts. No voxels were significant for reduced DR. Multiple comparisons were corrected for by threshold-free cluster enhancement with the threshold set at p<0.05, and the significant voxels are inflated for ease of viewing. The statistical maps are shown as overlays on the Montreal Neurological Institutes template (annotated with the corresponding y-coordinates). All significant changes shown reflect higher DR in Alzheimer's disease.