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. 2014 Jan 27;5:6. doi: 10.3389/fendo.2014.00006

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Copyright © 2014 Ivell, Heng and Anand-Ivell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Profiles through rat post-natal development for key circulating hormones of the HPG axis. LH (upper panel) is given as range to indicate the high degree of episodic secretion during early puberty, which is not represented in simple mean values (26). Testosterone (T; middle panel) concentrations are derived from Bartlett et al. (27) based on simple radioimmunassay. The profile for circulating INSL3 [lower panel; Ref. (10)] indicates the marked “overshoot” during early puberty, corresponding to the high LH variance (upper panel). Note that INSL3 values reduce to a stable lower concentration, concomitant with the asymptotic testosterone maximum, and the reduction in LH episodic fluctuation.