Table I.
Demographics and outcomes according to QTc interval
| Variables | Normal QTC interval ≤ 450 (M), ≤ 460 (F) (n = 337) | Prolonged QTc interval QTC > 450 ms (M), > 460 ms (F) (n = 122) | Value of p |
|---|---|---|---|
| Men, n (%) | 178 (53) | 72 (59) | 0.25 |
| Age, mean ± SD [years] | 65.6 ±16.8 | 65.3 ±17.1 | 0.98 |
| Caucasian race, n (%) | 245 (73) | 85 (70) | 0.56 |
| Prior syncope, n (%) | 80 (24) | 28 (23) | 0.99 |
| Prior cardiovascular disease, n (%) | 109 (32) | 54 (44) | 0.02 |
| OESIL! Score | < 0.001 | ||
| High risk SFSR$ score, n (%) | 191 (57) | 96 (79) | < 0.001 |
| Diabetes mellitus, n (%) | 74 (22) | 36 (30) | 0.1 |
| Hypertension, n (%) | 219 (65) | 101 (83) | < 0.001 |
| Dyslipidemia, n (%) | 153 (45) | 70 (57) | 0.02 |
| Coronary artery disease, n (%) | 73 (22) | 44 (36) | 0.002 |
| Congestive heart failure, n (%) | 6 (2) | 14 (11) | < 0.001 |
| Cerebrovascular accident/transient Ischemic attack, n (%) | 28 (8) | 17 (14) | 0.08 |
| History of malignancy, n (%) | 35 (10) | 21 (17) | 0.054 |
| Smoking, n (%) | 67 (20) | 30 (25) | 0.3 |
| Glomerular filtration rate [ml/min/1.73 m2] | 72 ±28 | 72 ±29 | 0.56 |
| QRS duration [ms] | 90 ±12 | 109 ±31 | < 0.001 |
| QRS T angle [degrees] | 47 ±41 | 74 ±55 | < 0.001 |
| Vasovagal syncope, n (%) | 70 (21) | 26 (21) | 0.89 |
| Syncopal etiology undetermined, n (%) | 103 (30) | 45 (37) | 0.21 |
| Volume depletion, n (%) | 32 (9) | 18 (15) | 0.12 |
| Cardiac causes of syncope*, n (%) | 83 (25) | 15 (12) | 0.004 |
| Mortality, n (%) | 41 (12) | 31 (25) | 0.001 |
*
Atrial and ventricular arrhythmias, second-degree or third-degree atrioventricular block, acute coronary syndrome, aortic stenosis, and hypertrophic obstructive cardiomyopathy; M – men, F – women
!
Osservatorio Epidemiologico sulla Sincope nel Lazio score
$
San Francisco syncope rule