Table 3.
Association Between Kidney Function Measures and Cardiovascular Mortality
| Kidney Function Measure, mL/min per 1.73 m2 |
Mortality per 100 Person-Years |
Unadjusted | Adjusteda | Adjustedb |
|---|---|---|---|---|
|
| ||||
| Hazard Ratio (95% Confidence Interval) | ||||
| Chronic Kidney Disease Epidemiology Collaboration eGFR quintile | ||||
| ≥75 | 2.6 | 1.56 (0.67–3.65) | 1.51 (0.64–3.55) | 1.48 (0.62–3.51) |
| 64–75 | 1.6 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| 55–63 | 2.2 | 1.29 (0.53–3.10) | 1.28 (0.53–3.08) | 1.19 (0.49–2.90) |
| 44–54 | 2.1 | 1.18 (0.48–2.90) | 1.10 (0.45–2.70) | 0.95 (0.38–2.35) |
| ≤ 43 | 4.7 | 2.73 (1.26–5.93) | 2.62 (1.21–5.70) | 1.98 (0.90–4.37) |
| eGFR Cystatin C quintile | ||||
| ≥75 | 1.6 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| 65–74 | 2.1 | 1.14 (0.69–1.87) | 1.02 (0.62–1.69) | 0.93 (0.56–1.54) |
| 52–64 | 2.4 | 1.23 (0.75–2.01) | 1.13 (0.69–1.84) | 0.98 (0.60–1.62) |
| <52 | 5.6 | 2.66 (1.75–4.04) | 2.18 (1.43–3.33) | 1.66 (1.06–2.60) |
a
Adjusted for age, sex, and race.
b
Additionally adjusted for hypertension, diabetes mellitus, smoking, body mass index, prevalent cardiovascular disease, prevalent heart failure, low- and high-density lipoprotein cholesterol, and C-reactive protein.
eGFR = estimated glomerular filtration rate.