Table 1.

Mean TEG parameters of normal blood obtained from healthy volunteers, blood with addition of heparin, blood with addition of fibrinogen, and blood with addition of both heparin and fibrinogen. Heparin significantly increased R-time and K-time, and reduced α-angle, MA, G, and thrombus generation. Fibrinogen significantly decreased R-time and K-time, and increased α-angle, MA, G, and thrombus generation. The addition of fibrinogen to heparinized blood negated the anticoagulant effects of heparin.

	Normal (n=10)	Heparin (n=10)	Fibrinogen (n=10)	Heparin + Fibrinogen (n=10)
R-time (min)	8.51±0.69	15.53±1.48*	5.93±0.19*	9.57±0.52
K-time (min)	3.16±0.3	6.99±0.51*	2.22±0.16*	4.92±0.75
α-angle (degrees)	51.74±2.1	30.27±1.78*	58.01±2.18*	41.03±3.14*
MA (mm)	60.48±1.43	52.79±1.5*	67.53±1.19*	61.39±1.29
G (dynes/cm2)	7.81±0.45	5.68±0.32*	10.58±0.52*	8.08±0.41
Thrombus Generation (mm/min)	736.2±18.1	651.7±18.4*	825.9±14.7*	736.2±19.2

^*p < 0.05 compared to normal blood.