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. Author manuscript; available in PMC: 2014 Jan 27.
Published in final edited form as: Mol Imaging Biol. 2012 Apr;14(2):213–224. doi: 10.1007/s11307-011-0485-3

Table 5.

Organ doses to the 70 kg adult human model in OLINDA/EXM 1.1 using humanized time-integrated activity coefficients from rhesus macaques after intravenous administration of 18F-FACE (mSv/MBq)

Target organ Male Female All Male Female
1 2 3 4 5 6 Mean±SD Mean±SD Mean±SD
Adrenals 0.016 0.014 0.013 0.010 0.012 0.013 0.013±0.002 0.014±0.002 0.012±0.002
Brain 0.007 0.007 0.009 0.005 0.008 0.010 0.008±0.002 0.008±0.001 0.007±0.002
Breasts 0.008 0.008 0.008 0.005 0.008 0.009 0.008±0.001 0.008±0.001 0.007±0.002
Gallbladder wall 0.031 0.033 0.017 0.040 0.036 0.016 0.029±0.010 0.027±0.008 0.031±0.013
LLI wall 0.058 0.096 0.120 0.060 0.062 0.052 0.075±0.027 0.091±0.031 0.058±0.005
Small intestine 0.031 0.045 0.055 0.029 0.031 0.029 0.037±0.011 0.044±0.012 0.030±0.002
Stomach wall 0.013 0.013 0.014 0.009 0.012 0.013 0.012±0.002 0.013±0.001 0.011±0.002
ULI wall 0.045 0.071 0.088 0.045 0.047 0.040 0.056±0.019 0.068±0.021 0.044±0.003
Heart wall 0.035 0.038 0.020 0.027 0.015 0.017 0.025±0.010 0.031±0.010 0.019±0.006
Kidneys 0.046 0.032 0.034 0.026 0.042 0.026 0.034±0.008 0.037±0.008 0.031±0.010
Liver 0.067 0.041 0.014 0.032 0.015 0.017 0.031±0.021 0.040±0.026 0.021 ±0.009
Lungs 0.011 0.010 0.010 0.007 0.009 0.011 0.010±0.002 0.010±0.001 0.009±0.002
Muscle 0.010 0.010 0.011 0.007 0.010 0.011 0.010±0.002 0.010±0.001 0.009±0.002
Ovaries NA NA NA 0.013 0.017 0.018 0.016±0.002 N/A 0.016±0.002
Pancreas 0.016 0.014 0.014 0.010 0.013 0.014 0.013±0.002 0.015±0.001 0.012±0.002
Red marrow 0.011 0.011 0.012 0.007 0.010 0.011 0.010±0.002 0.011±0.001 0.009±0.002
Osteogenic cells 0.014 0.014 0.016 0.010 0.014 0.017 0.014±0.003 0.015±0.001 0.014±0.004
Skin 0.007 0.007 0.008 0.005 0.007 0.009 0.007±0.001 0.008±0.001 0.007±0.002
Spleen 0.012 0.011 0.012 0.008 0.011 0.013 0.011±0.002 0.012±0.001 0.010±0.003
Testes 0.009 0.009 0.010 NA NA NA 0.009±0.001 0.009±0.001 NA
Thymus 0.010 0.010 0.010 0.007 0.009 0.011 0.010±0.002 0.010±0.001 0.009±0.002
Thyroid 0.009 0.009 0.010 0.006 0.009 0.011 0.009±0.002 0.009±0.001 0.009±0.003
Urinary bladder wall 0.042 0.015 0.017 0.014 0.017 0.021 0.021±0.010 0.025±0.015 0.017±0.004
Uterus NA NA NA 0.011 0.014 0.016 0.014±0.003 NA 0.014±0.003
Total body 0.012 0.012 0.012 0.008 0.010 0.012 0.011±0.002 0.012±0.001 0.010±0.002
EDE 0.024 0.027 0.030 0.019 0.021 0.019 0.023±0.004 0.027±0.003 0.020±0.001
ED 0.022 0.025 0.028 0.016 0.018 0.018 0.021±0.004 0.025±0.003 0.018±0.001

EDE effective dose equivalent, ED effective dose, LLI lower large intestine, ULI upper large intestine, NA not applicable