Skip to main content
. Author manuscript; available in PMC: 2014 Jan 27.
Published in final edited form as: Nat Rev Gastroenterol Hepatol. 2013 Mar 19;10(6):362–370. doi: 10.1038/nrgastro.2013.36

Figure 2.

Figure 2

The structure of the pancreatic acinar cell. Pancreatic digestive enzymes are processed within the RER located primarily in the basal domain of these cells. The RER is where folding, glycosylation and disulphide bond formation occurs during protein synthesis. From here, the digestive enzymes are transported to the Golgi where they are sorted and packaged into condensing vesicles. The condensing vesicles are compacted to form mature zymogen granules and are transported to the apical end of the cell in position for regulated secretion into the duct lumen. Abbreviation: RER, rough endoplasmic reticulum. Permission obtained from Nature Publishing Group © Adapted from Whitcomb, D. C.