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. Author manuscript; available in PMC: 2014 Jan 27.
Published in final edited form as: Endocr Relat Cancer. 2010 Nov 30;18(1):27–37. doi: 10.1677/ERC-10-0185

Figure 4.

Figure 4

The area under time–activity curve (AUC) of thyroid in wild-type (WT) mice is markedly increased by 30 mg/kg 17-AAG. WT mice (15–18 months) were weighed and injected with 30 mg/kg 17-AAG in 50 μl DMSO. Na123I (100–150 μCi) was injected into mice at 3 h post 17-AAG injection. SPECT images were acquired at t1(4), t6(9), and t24(27) post Na123I injection (time post 17-AAG injection). At t1, the extent of thyroidal radioiodine accumulation was quite comparable between DMSO versus 17-AAG-treated mice, suggesting that 17-AAG had minimal effect on thyroidal iodide influx. However, at t24, the extent of thyroidal radioiodine accumulation was markedly increased (P value=0.15) in 17-AAG-treated mice versus that in DMSO-treated mice, suggesting that 17-AAG increased iodide retention ability. Consequently, the exposure of thyroid with radioiodine over time was markedly increased by 17-AAG as defined by the AUC.