Table 2.

Effect of 17-allyamino-17-demothoxygeldanamycin (17-AAG) on thyroidal radioiodine accumulation in wild-type (WT) and thyroglobulin (Tg)-PTC1 mice

		Thyroidal %ID			Iodide retention ability
Mice	Treatment	t1	t6	t24	6 h/1 h	24 h/1 h	AUCa
WT	DMSO	2.6±1.3	9.3±4.1	11.2±7.9	3.6±0.2	4.3±1.6	224.4±133.2
	17-AAG	2.7±1.8	13.0±6.6	43.4±30.1	6.3±3.4	15.7±0.9	583.1±362.1
Tg-PTC1	DMSO	7.4±5.6	8.8±5.1	3.0±0.7	1.3±0.3	0.6±0.6	148.8±44.3
	17-AAG	9.2±1.0	16.7±2.9	22.6±4.7	1.9±0.5	2.6±0.6	442.6±62.7

^aAUC, area under time–activity curve; it is calculated by ${\int }_{\mathrm{t}=1\mathrm{h}}^{\mathrm{t}=24\mathrm{h}}f\left(t\right)dt$; f(t), thyroidal %ID; t, time (h).