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The Spt6, Ctk1 and the PAF complex are important to maintain histone levels. (A) Immunoblot analysis of histone H3 from the lysates prepared from asynchronous log phase cultures of the indicated mutant strains in comparison to their isogenic WT counterparts. (B) Upstream regulators of the Spt6–Ctk1 loop (PAF) and the loop members themselves are sensitive to HU. Serial 10-fold dilutions of yeast strains of the indicated paf or ctk1 mutations were plated on 25 mM HU plates for 3 days.
