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. 2013 Oct 8;42(2):727–738. doi: 10.1093/nar/gkt907

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Relative changes of the average time for location of the operator by LacI tetramer. (A) Microscopic association constant is optimized for fast target location. The times are given with respect to the minimal value. (B) The minimum of the time as a function of the microscopic dissociation rate constant is shifted by 1 order of magnitude from determined value. However, the decrease of the time is only by a factor 1.66. The dashed lines point to determined values of microscopic rate constants.