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. 2013 Oct 16;42(2):1139–1151. doi: 10.1093/nar/gkt909

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Reciprocal effects of decreased or increased dADAR expression on motor neuron excitability in Adar^5G1 mutant or Adar 3/4S-overexpressing larvae. (A) Examples of single aCC neuron activity recordings from wild-type, Adar^5G1, RRa>Adar siRNA and RRa>Adar 3/4S OE larvae viewed over 3-min time scales. On the right top corner of each spike train is a 5 ms zoomed-in view showing true action potential spikes in the spike train. (B–D) Quantification of firing activities. The bars represent the averages of 4–8 recordings of different aCC cells. Error bars are SEM. ***FDR P < 1E-6, ****FDR P < 1E-50 (Poisson exact test). Genotypes are WT: UAS-GFP; RRa- GAL4. RRa>Adar 3/4S OE: UAS-GFP/+; RRa-GAL4/UAS-Adar 3/4S. Adar^5G1: Adar^5G1; UAS-GFP/+; RRa-GAL4/+. RRa>Adar siRNA: UAS-GFP/+; RRa-GAL4/UAS-Adar siRNA.